These tiny creatures, sometimes called water bears, can survive radiation, freezing, extreme dehydration and even the vacuum of space.
Researchers have now decoded the DNA of two species of tardigrade and uncovered the genes that allow them to be revived after desiccation.
The study has been published in the journal, PLOS Biology.
Just a millimetre or less in size, tardigrades are believed to be the toughest creatures on Earth. A recent study found that they could survive almost any cosmic disaster that could hit the planet.
Tardigrades are often found in locations that dry out such as in moss and in ponds. Over time they have acquired the ability to survive extreme dehydration and spring back to life years later in the presence of water.
In this new paper, scientists found that the key to their survival is genetic. Dry conditions trigger some of the creature's genes to produce proteins which replace missing water in their cells. Once water is available again it refills the cells dissolving the proteins.
The researchers say understanding this innate survival ability of tardigrades could have benefits for humans, such as allowing live vaccines to be posted around the world and stored without refrigeration.